Aim’s 3D models eliminate the need for costly and ancillary hardware traditionally required with 3D cell culture approaches
Which 3D cell culture model for cancer research is right for you?
3D cell cultures closely resemble the properties observed in vivo, heavily sought in the application of stem cell culture, cancer research, drug and toxicity screening, and tissue engineering for cancer therapy. In principle, 3D models can be divided into:
Suspension cultures on non-adherent plates
Cultures in gel-like substances
Cultures on a scaffold
Depending on the nature of culture chosen, cell behavior differs in many aspects and therefore the efficiency, lifespan, repeatability, cost, and ease of work are varying. During the selection of 3D cell culture model, consideration should be given to the nature of the cells (cell line, primary cell, tissue origin) and the objective of the study and its end point measurement. At all possible, an ideal 3D cell culture model not only recapitulate 3D microphysiological system of chosen cell type but also to accommodate existing workflow and confirmatory analysis. Apart from this, testing outcomes could differ from each mode of 3D cell culture used. For instance, unlike Boyden chamber assay that is tedious and requiring large number of cells to capture signal and cell movement cannot be visualized in cell migration assay, the AIM chips are useful in studying live cell migration within a 3D matrix where the migration trajectories of live cells can be monitored in real time. Same set of cells subjected to downstream analysis ensure results reproducibility. Therefore, it’s crucial to evaluate these parameters before starting the 3D cell culture to maximize gain.
Low cost and achieve up to 80% saving on consumables
Despite the advantages of using 3D cell culture models, cost of operation remains a challenge. No matter who the users are, we need to find ways to reduce costs while maximizing process efficiency. Extraneous equipment, dedicated incubator, specialized extracellular matrix and media as well as precious cells represent a significant portion of the costs for 3D cell-based assay. Aim’s 3D models eliminate the need for costly and ancillary hardware traditionally required with 3D cell culture approaches. Moreover, as low as only 10µL of extracellular matrixes and 20 µl of cell suspension used in single experiment using AIM chips, saving up to 80% of reagents and cells used compared to 96-well plates format. This offers cost-effective experimentation by saving on facility cost, space, and consumables.
Qualified by application and scalable
Cancer research using 3D culture program is incredibly time and resource consuming at the initial phase, along with the amount of technical training time required to achieve 3D culture competency. Ultimately, we expect that research outcomes will play an important role in providing clinically relevant results that accelerate the development of therapies. Extensive validation testing performed using Aim Chips provides users application-qualified protocol, including cell migration, immune check-point modulation, T-cell efficiency, spheroid invasion, and angiogenesis and therefore offering a good starting point to enter 3D cell culture world. Moreover, this system is resilience enough to scale up or down over time. This built in scalability ready for high throughout production with no specialized expertise or extensive training required.
Whether you’re just looking to start 3D cell culture in cancer research, searching for proven ways to high throughput screening, talk to our team about how this innovative method could improve your cell culture processes.
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Aim’s 3D models eliminate the need for costly and ancillary hardware traditionally required with 3D cell culture approaches
Which 3D cell culture model for cancer research is right for you?
3D cell cultures closely resemble the properties observed in vivo, heavily sought in the application of stem cell culture, cancer research, drug and toxicity screening, and tissue engineering for cancer therapy. In principle, 3D models can be divided into:
Depending on the nature of culture chosen, cell behavior differs in many aspects and therefore the efficiency, lifespan, repeatability, cost, and ease of work are varying. During the selection of 3D cell culture model, consideration should be given to the nature of the cells (cell line, primary cell, tissue origin) and the objective of the study and its end point measurement. At all possible, an ideal 3D cell culture model not only recapitulate 3D microphysiological system of chosen cell type but also to accommodate existing workflow and confirmatory analysis. Apart from this, testing outcomes could differ from each mode of 3D cell culture used. For instance, unlike Boyden chamber assay that is tedious and requiring large number of cells to capture signal and cell movement cannot be visualized in cell migration assay, the AIM chips are useful in studying live cell migration within a 3D matrix where the migration trajectories of live cells can be monitored in real time. Same set of cells subjected to downstream analysis ensure results reproducibility. Therefore, it’s crucial to evaluate these parameters before starting the 3D cell culture to maximize gain.
Low cost and achieve up to 80% saving on consumables
Despite the advantages of using 3D cell culture models, cost of operation remains a challenge. No matter who the users are, we need to find ways to reduce costs while maximizing process efficiency. Extraneous equipment, dedicated incubator, specialized extracellular matrix and media as well as precious cells represent a significant portion of the costs for 3D cell-based assay. Aim’s 3D models eliminate the need for costly and ancillary hardware traditionally required with 3D cell culture approaches. Moreover, as low as only 10µL of extracellular matrixes and 20 µl of cell suspension used in single experiment using AIM chips, saving up to 80% of reagents and cells used compared to 96-well plates format. This offers cost-effective experimentation by saving on facility cost, space, and consumables.
Qualified by application and scalable
Cancer research using 3D culture program is incredibly time and resource consuming at the initial phase, along with the amount of technical training time required to achieve 3D culture competency. Ultimately, we expect that research outcomes will play an important role in providing clinically relevant results that accelerate the development of therapies. Extensive validation testing performed using Aim Chips provides users application-qualified protocol, including cell migration, immune check-point modulation, T-cell efficiency, spheroid invasion, and angiogenesis and therefore offering a good starting point to enter 3D cell culture world. Moreover, this system is resilience enough to scale up or down over time. This built in scalability ready for high throughout production with no specialized expertise or extensive training required.
Whether you’re just looking to start 3D cell culture in cancer research, searching for proven ways to high throughput screening, talk to our team about how this innovative method could improve your cell culture processes.
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