Vaccine development workflows vary depending upon the platform chosen. The various approaches to vaccine development can be broadly classified into either protein subunit, plasmid DNA, mRNA, or viral vaccines. From the identification, synthesis, and optimization of targets to vaccine production, delivery, and testing, Thermo Fisher Scientific provides expertise and an unparalleled array of reliable and scalable tools, services, and support to help you accelerate your productivity and innovation
Vaccine Research and Development: Keeping it clean with Molecular Grade Chemicals
Molecular workflows in vaccine discovery and development
Vaccine development workflows vary depending upon the platform chosen. The various approaches to vaccine development can be broadly classified into either protein subunit, plasmid DNA, mRNA, or viral vaccines. From the identification, synthesis, and optimization of targets to vaccine production, delivery, and testing, Thermo Fisher Scientific provides expertise and an unparalleled array of reliable and scalable tools, services, and support to help you accelerate your productivity and innovation
Molecular grade chemicals and reagents play a critical role in vaccine development. These chemicals are tested for specific contaminants, such as nucleases and bacteria, where appropriate. This chemical grade is also included in the manufacturing and testing of pharmaceutical products, medical devices, biologics, cell- and tissue-based products, and many other healthcare-related solutions.
What chemicals do you need for different methods/protocols?
Molecular Biology Grade Isopropanol
Molecular Biology Grade Ethanol 100%, 96%, 80% and 70%
Tris EDTA (TE) Buffer
Tris Buffer
DNTP set
Real Time PCR
Tris-Borate-EDTA (TBE) buffer
Tris-Acetate-EDTA (TAE) buffer
Tris EDTA (TE) Buffer
Tris Buffer
NGS Library Preparation
Tris-Borate-EDTA (TBE) buffer
Tris-Acetate-EDTA (TAE) buffer
Tris EDTA (TE) Buffer
Tris Buffer
Candidate Synthesis
Gene synthesis and mRNA synthesis
Molecular Biology Grade Isopropanol
Molecular Biology Grade Ethanol 100%, 96%, 80% and 70%
Tris-Borate-EDTA (TBE) buffer
Tris-Acetate-EDTA (TAE) buffer
Tris EDTA (TE) Buffer
Tris Buffer
DNTP set
Candidate Characterization
mRNA vaccine-identity and biodistribution studies
Molecular Biology Grade Isopropanol
Molecular Biology Grade Ethanol 100%, 96%, 80% and 70%
Tris-Borate-EDTA (TBE) buffer
Tris-Acetate-EDTA (TAE) buffer
Tris EDTA (TE) Buffer
Tris Buffer
FASTRunâ„¢ Tris SDS PAGE Running Buffer
Sodium Dodecyl Sulfate SDS Micropellets
Finding the Right Molecular Biology Grade Chemical for Your Lab
Within the Thermo Fisher Scientific life science lab essentials portfolio, researchers have a great choice of products with different specifications.
We offer products that can be used as high-quality ingredients in the formulation of solutions, buffers, media and gels for various stages of many life science workflows.
This is an ultrapure molecular biology grade ethanol used for the purification and precipitation of biomolecules such as nucleic acids and proteins.
Applications:
Purification and precipitation of nucleic acids (DNA and RNA) and proteins
Staining and destaining solutions
Cell and tissue dehydration prior to embedding
Extraction medium
Chromatographic reagent
Guanidinium Thiocyanate (GITC)
Lysis buffers for nucleic acid extraction
Guanidine thiocyanate is a potent chaotropic agent; thus, by interfering with the hydrogen bond network in aqueous solutions, it has a destabilising effect on macromolecules, especially proteins.
It is commonly used in cells and the lysis processes in virus particles to extract nucleic acids, as it denatures RNAse and DNAse enzymes1 that would otherwise damage the extract.2
GITC lysis buffers to extract viral RNA are in growing demand, linked to the use of polymerase chain reaction (PCR) based assay.
Ultrapure qPCR and RT-qPCR Water
Consistent Results for Critical Molecular Biology Applications
Fisher Bioreagents™ ultrapure qPCR-grade water was developed specifically for quantitative PCR (qPCR) and reverse transcription PCR (RT-qPCR). It’s free of hydrolytic enzymes that can degrade the target nucleic acid and interfere with amplification, and tested to ensure the absence of human genomic and E. coli DNA. With this new grade of water, you can be confident that the potential for a false-positive signal is minimized.
Key Features:
DNase, RNase, Protease and Nickase-free
Tested for nucleic acid contamination (E. coli DNA, human genomic DNA)
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Vaccine Research and Development: Keeping it clean with Molecular Grade Chemicals
Molecular workflows in vaccine discovery and development
Vaccine development workflows vary depending upon the platform chosen. The various approaches to vaccine development can be broadly classified into either protein subunit, plasmid DNA, mRNA, or viral vaccines. From the identification, synthesis, and optimization of targets to vaccine production, delivery, and testing, Thermo Fisher Scientific provides expertise and an unparalleled array of reliable and scalable tools, services, and support to help you accelerate your productivity and innovation
Molecular grade chemicals and reagents play a critical role in vaccine development. These chemicals are tested for specific contaminants, such as nucleases and bacteria, where appropriate. This chemical grade is also included in the manufacturing and testing of pharmaceutical products, medical devices, biologics, cell- and tissue-based products, and many other healthcare-related solutions.
What chemicals do you need for different methods/protocols?
Water
Molecular Biology Grade Isopropanol
Tris-Borate-EDTA (TBE) buffer
Tris-Acetate-EDTA (TAE) buffer
Triton-X-100
Guanidine thiocyanate
Molecular Biology Grade Ethanol 100%, 96%, 80% and 70%
Tris EDTA (TE) Buffer
Tris Buffer
DNTP set
Tris-Acetate-EDTA (TAE) buffer
Tris EDTA (TE) Buffer
Tris Buffer
Tris-Acetate-EDTA (TAE) buffer
Tris EDTA (TE) Buffer
Tris Buffer
Molecular Biology Grade Ethanol 100%, 96%, 80% and 70%
Tris-Borate-EDTA (TBE) buffer
Tris-Acetate-EDTA (TAE) buffer
Tris EDTA (TE) Buffer
Tris Buffer
DNTP set
Molecular Biology Grade Ethanol 100%, 96%, 80% and 70%
Tris-Borate-EDTA (TBE) buffer
Tris-Acetate-EDTA (TAE) buffer
Tris EDTA (TE) Buffer
Tris Buffer
FASTRunâ„¢ Tris SDS PAGE Running Buffer
Sodium Dodecyl Sulfate SDS Micropellets
Finding the Right Molecular Biology Grade Chemical for Your Lab
Within the Thermo Fisher Scientific life science lab essentials portfolio, researchers have a great choice of products with different specifications.
We offer products that can be used as high-quality ingredients in the formulation of solutions, buffers, media and gels for various stages of many life science workflows.
Featured Products:
Fisher Bioreagentsâ„¢ Absolute Ethanol (200 proof)
This is an ultrapure molecular biology grade ethanol used for the purification and precipitation of biomolecules such as nucleic acids and proteins.
Applications:
Guanidinium Thiocyanate (GITC)
Lysis buffers for nucleic acid extraction
Guanidine thiocyanate is a potent chaotropic agent; thus, by interfering with the hydrogen bond network in aqueous solutions, it has a destabilising effect on macromolecules, especially proteins.
It is commonly used in cells and the lysis processes in virus particles to extract nucleic acids, as it denatures RNAse and DNAse enzymes1 that would otherwise damage the extract.2
GITC lysis buffers to extract viral RNA are in growing demand, linked to the use of polymerase chain reaction (PCR) based assay.
Ultrapure qPCR and RT-qPCR Water
Consistent Results for Critical Molecular Biology Applications
Fisher Bioreagents™ ultrapure qPCR-grade water was developed specifically for quantitative PCR (qPCR) and reverse transcription PCR (RT-qPCR). It’s free of hydrolytic enzymes that can degrade the target nucleic acid and interfere with amplification, and tested to ensure the absence of human genomic and E. coli DNA. With this new grade of water, you can be confident that the potential for a false-positive signal is minimized.
Key Features:
Additional Resources:
Alfa Lysis BufferAbsolute Ethanol (200 proof)
Ultrapure Water for aPCR & RT-qPRC
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